Questions about Mitochondrial Diseases?

Victor Macallister: 1. optic atrophy: loss of vision, especially color visionFriedreich's ataxia: muscle weakness, loss of coordination, hearing loss, slurred speech, curved spine, diabetes heart disordershereditary spastic paraplegia: constant stiffness of muscles2. all of them are caused by mutations in the mitochondrial DNA that makes the mitochondria dysfunctional and unable to support the affect cell (which then dies)3. most of these diseases are caused by inherited mitochondrial DNA mutations, thus onset is early. Many of these diseases are fatal, so the affected children will not reach maturity (though that is not the case for all of these diseases. In fact, Alzheimer's is considered a mitochondrial disease, but it has a late onset since it takes years for the accumulation of reactive oxygen species to mutate the mitochondrial DNA to such a degree that it becomes dysfunctional)4. the diseases are inherited through the maternal line, meaning that if your mother ha! s the disease, you are more likely to have the disease, but if your father has the disease, you are no more likely to develop it than anybody else.5. maternal inheritance means that the mitochondrial DNA is only inherited from the mother, not father. That is because during the fusing of the egg and sperm, the sperm's mitochondria are always destroyed and so only the egg's mitochondria replicate....Show more

Keven Woodington: making use of all the genealogies in the Bible, human beings pass returned a minimum of 20,000 years to as much as 60,000 years. Y-chromosomal Adam does not pass returned as far as Mitochondrial Eve it is extremely data that the Bible is real. the three better halves on the Ark weren't appropriate so mitochondrial Eve is going returned to Eve. however the three brothers have been appropriate so Y-chromosomal Adam basically is going returned to Noah. data does not rely to those that do no longer choose to have self assurance....Show more